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White Sox at Royals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 5

Its Monday, May 5 and the White Sox (10-24) are in Kansas City to take on the Royals (19-16). Shane Smith is slated to take the mound for Chicago against Cole Ragans for Kansas City.

The White Sox are 10-24, but picked up the series win over the Houston Astros with a 5-4 win yesterday.

The Royals are one of the hottest teams in the MLB. They have won eight of their last 10 games and are now third in the AL Central.

With an 11-6 win over the Baltimore Orioles, the Royals have now won four straight series.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch White Sox at Royals

Date: Monday, May 5, 2025
Time: 7:40PM EST
Site: Kauffman Stadium
City: Kansas City, MO
Network/Streaming: FanDuel Sports Network Kansas City, CHSN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the White Sox at the Royals

The latest odds as of Monday:

Moneyline: White Sox (+200), Royals (-244)
Spread: Royals -1.5
Total: 8.0 runs

Probable starting pitchers for White Sox at Royals

Pitching matchup for May 5, 2025: Shane Smith vs. Cole Ragans
- White Sox: Shane Smith, (1-1, 2.23 ERA)
  Last outing (Milwaukee Brewers, 4/30): 5.0 Innings Pitched, 1 Earned Runs Allowed, 6 Hits Allowed, 3 Walks, and 4 Strikeouts
- Royals: Cole Ragans, (1-1, 4.40 ERA)
  Last outing (Colorado Rockies, 4/24): 3.0 Innings Pitched, 4 Earned Runs Allowed, 3 Hits Allowed, 2 Walks, and 4 Strikeouts

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Top betting trends & insights to know ahead of White Sox at Royals

The Royals have won 16 of their last 19 home matchups against the White Sox
The White Sox’s last 6 road trips to the Royals have stayed under the Total
The Royals have covered in 4 of their last 5 games for a profit of 1.32 units

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the White Sox and the Royals

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday’s game between the White Sox and the Royals:

Moneyline: NBC Sports Bet is recommending a play on the Kansas City Royals on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago White Sox at +1.5.
Total: NBC Sports Bet is staying away from a play on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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