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Twins at Brewers prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 16

Its Friday, May 16 and the Twins (24-20) are in Milwaukee to take on the Brewers (21-23).

Joe Ryan is slated to take the mound for Minnesota against Chad Patrick for Milwaukee.

The Twins have won 11 straight. Their most recent victims were the Orioles. Minnesota took three from them in Baltimore before arriving in Milwaukee. They shut out the O’s yesterday, 4-0. Chris Paddack and two relievers limited the Orioles to just six hits and seven total baserunners.

Milwaukee was off yesterday. They have lost four of their last six including two of three earlier this week in Cleveland. They were shut out twice by the Guardians before bouncing back with a 9-5 win, Wednesday. Rhys Hoskins had four hits and drove in five runs in the win.

Lets dive into tonight’s matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Twins at Brewers

Date: Friday, May 16, 2025
Time: 8:10PM EST
Site: American Family Field
City: Milwaukee, WI
Network/Streaming: MNNT, FDSNWI

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Twins at the Brewers

The latest odds as of Friday:

Moneyline: Twins (-113), Brewers (-106)
Spread: Twins -1.5
Total: 7.0 runs

Probable starting pitchers for Twins at Brewers

Pitching matchup for May 16, 2025: Joe Ryan vs. Chad Patrick
- Twins: Joe Ryan (3-2, 2.74 ERA)
  Last outing: 5/10 vs. San Francisco - 6IP, 1ER, 2H, 0BB, 7Ks
- Brewers: Chad Patrick (2-3, 3.19 ERA)
  Last outing: 5/11 at Tampa Bay - 4.1IP, 2ER, 6H, 2BB, 4Ks

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Top betting trends & insights to know ahead of Twins at Brewers

The Brewers have won 4 of their last 5 home games against American League teams
8 of the Twins’ last 10 games with the Brewers have gone over the Total
In their last 5 games with a rest advantage, the Brewers are 1-4 on the Run Line
Trevor Larnach had his modest 6-game hitting streak snapped on Thursday

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Twins and the Brewers

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday’s game between the Twins and the Brewers:

Moneyline: NBC Sports Bet is recommending a play on the Milwaukee Brewers on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Milwaukee Brewers at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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