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Tigers at Cardinals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21

Its Wednesday, May 21 and the Tigers (32-17) are in St. Louis to take on the Cardinals (27-22).

Brant Hurter is slated to take the mound for Detroit against Andre Pallante for St. Louis.

Detroit evened the series at one game apiece with a 5-4 win last night. The Tigers squandered a 4-0 lead but won it in the ninth thanks to an RBI double from Riley Greene.

Lets dive into this afternoon’s matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Tigers at Cardinals

Date: Wednesday, May 21, 2025
Time: 1:15PM EST
Site: Busch Stadium
City: St. Louis, MO
Network/Streaming: FDSNDT, FDSNMW, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Tigers at the Cardinals

The latest odds as of Wednesday:

Moneyline: Tigers (-104), Cardinals (-112)
Spread: Cardinals 1.5
Total: 8.0 runs

Probable starting pitchers for Tigers at Cardinals

Pitching matchup for May 21, 2025: Brant Hurter vs. Andre Pallante
- Tigers: Brant Hurter (1-0, 2.35 ERA)
  Last outing: 5/18 at Toronto - 0.1IP, 0ER, 0H, 0BB, 1K
- Cardinals: Andre Pallante (4-2, 4.11 ERA)
  Last outing: 5/16 at Kansas City - 7IP, 2ER, 7H, 0BB, 4Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Tigers at Cardinals

The Tigers have won 4 of their last 5 games against National League teams
The Over is 4-6 in the Cardinals’ last ten home games this season
The Cardinals have covered in 4 of their last 5 games showing a profit of 2.31 units
Nolan Arenado is 4-20 (.200) over his last 5 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for today’s game between the Tigers and the Cardinals

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Tigers and the Cardinals:

Moneyline: NBC Sports Bet is recommending a play on the Detroit Tigers on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Detroit Tigers at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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