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Pirates at Phillies Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 16

It’s Friday, May 16, and the Pirates (15-29) are in Philadelphia to take on the Phillies (25-18). Andrew Heaney is slated to take the mound for Pittsburgh against Ranger Suárez for Philadelphia.

Pittsburgh and Philadelphia are both coming off rest days ahead of this matchup. The Pirates earned a 4-0 win over the Mets to avoid the sweep in their last outing, while the Phillies dropped a 14-7 barnburner to the Cardinals. Pittsburgh is 3-10 since the start of May, while Philly is 8-5.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Pirates at Phillies

Date: Friday, May 16, 2025
Time: 6:45 PM EST
Site: Citizens Bank Park
City: Philadelphia, PA
Network/Streaming: SNP, NBCSP

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Pirates at the Phillies

The latest odds as of Friday:

Moneyline: Pirates (+186), Phillies (-225)
Spread: Phillies -1.5
Total: 8.0 runs

Probable starting pitchers for Pirates at Phillies

Pitching matchup for May 16, 2025: Andrew Heaney vs. Ranger Suárez
- Pirates: Andrew Heaney, (2-3, 3.15 ERA)
  Last outing: 6.0 Innings Pitched, 2 Earned Runs Allowed, 4 Hits Allowed, 3 Walks, and 2 Strikeouts
- Phillies: Ranger Suárez, (1-0, 5.91 ERA)
  Last outing: 7.0 Innings Pitched, 0 Earned Runs Allowed, 3 Hits Allowed, 1 Walk, and 5 Strikeouts

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Expert picks & predictions for tonight’s game between the Pirates and the Phillies

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday’s game between the Pirates and the Phillies:

Moneyline: NBC Sports Bet is recommending a play on the Philadelphia Phillies on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Pittsburgh Pirates at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Pirates at Phillies

With Ranger Suarez opening the Phillies have won 3 straight home head-to-heads against the Pirates
The Over has cashed in 4 of the Phillies’ last 5 home games with Ranger Suarez on the mound
The Phillies returned a 4.25-unit profit on the Run Line last season with Ranger Suarez as the starter

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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