4 hours ago 1

Pirates at Cardinals prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 6

Its Paul Skenes day! Thhe Pirates (12-24) are in St. Louis to take on the Cardinals (17-19).

Paul Skenes is slated to take the mound for Pittsburgh against Matthew Liberatore for St. Louis.

With such lofty expectations, Skenes is likely hoping to turn his season around. He’s started 3-3, but has lost two of his last three games. In his loss to the Guardians, he only gave up two earned runs and walked just one batter. The run support was not there for the Pirates.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Pirates at Cardinals

Date: Tuesday, May 6, 2025
Time: 7:45PM EST
Site: Busch Stadium
City: St. Louis, MO
Network/Streaming: FanDuel Sports Network Midwest, SportsNet-PIT

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Pirates at the Cardinals

The latest odds as of Tuesday:

Moneyline: Pirates (-133), Cardinals (+112)
Spread: Pirates -1.5
Total: 7.0 runs

Probable starting pitchers for Pirates at Cardinals

Pitching matchup for May 6, 2025: Paul Skenes vs. Matthew Liberatore
- Pirates: Paul Skenes, (3-3, 2.74 ERA)
  Last outing (Chicago Cubs, 5/1): 5.0 Innings Pitched, 3 Earned Runs Allowed, 5 Hits Allowed, 4 Walks, and 2 Strikeouts
- Cardinals: Matthew Liberatore, (2-3, 3.44 ERA)
  Last outing (Cincinnati Reds, 5/1): 3.0 Innings Pitched, 2 Earned Runs Allowed, 1 Hits Allowed, 1 Walks, and 2 Strikeouts

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Pirates at Cardinals

The Pirates are 1-4 in their last 5 games
The Over is 4-1 in the Cardinals’ last 5 matchups against National League teams
It has been 4 games since the Pirates last covered the Run Line

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Pirates and the Cardinals

Rotoworld Best Bet

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Pirates and the Cardinals:

Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the St. Louis Cardinals at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff: