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NFL Week 4 betting: Odds, lines and totals for every game

    Sep 22, 2025, 12:58 PM ET

    Week 4 gets underway with a matchup of NFC West rivals when the Arizona Cardinals host the Seattle Seahawks on "Thursday Night Football."

    Sunday night features Micah Parsons and the Green Bay Packers hitting the road to take on the Dallas Cowboys.

    The week wraps up with a "Monday Night Football" doubleheader, as the New York Jets visit the Miami Dolphins (7:15 p.m. ET on ESPN) and the Denver Broncos host the Cincinnati Bengals (8:15 p.m. ET on ABC).

    Here's a look at the odds for every Week 4 game.

    Odds as of publication time. For the most current odds, visit ESPN BET.

    Jump to:
    SEA-ARI | MIN-PIT | NO-BUF | LAC-NYG
    WSH-ATL | PHI-TB | CLE-DET | CAR-NE
    TEN-HOU | JAX-SF | IND-LAR | CHI-LV
    BAL-KC | GB-DAL | NYJ-MIA | CIN-DEN


    Seattle Seahawks vs. Arizona Cardinals -1.5
    Thursday, 8:15 p.m., Prime Video


    Money Line: Seahawks (-105); Cardinals (-115)
    Total: 43.5; Opened: 44.5
    FPI favorite: Cardinals by 0.8 with a 52.47% probability to win the game outright


    Minnesota Vikings -2.5 vs. Pittsburgh Steelers
    Sunday, 9:30 a.m., NFL Net, NFL+


    Money Line: Vikings (-150); Steelers (+130)
    Total: 40.5; Opened: 41.5
    FPI favorite: Vikings by 3.1 with a 57.18% probability to win the game outright


    New Orleans Saints vs. Buffalo Bills -15.5
    Sunday, 1 p.m., CBS


    Money Line: Saints (+900); Bills (-1800)
    Total: 47.5; Opened: 48.5
    FPI favorite: Bills by 13.3 with a 79.67% probability to win the game outright


    Los Angeles Chargers -6.5 vs. New York Giants
    Sunday, 1 p.m., CBS


    Money Line: Chargers (-280); Giants (+230)
    Total: 44.5; Opened: 45.5
    FPI favorite: Chargers by 6.8 with a 67.8% probability to win the game outright


    Washington Commanders -2.5 vs. Atlanta Falcons
    Sunday, 1 p.m., CBS


    Money Line: Commanders (-145); Falcons (+125)
    Total: 44.5; Opened: 46.5
    FPI favorite: Commanders by 3.8 with a 59.33% probability to win the game outright


    Philadelphia Eagles -3.5 vs. Tampa Bay Buccaneers
    Sunday, 1 p.m., FOX


    Money Line: Eagles (-170); Buccaneers (+145)
    Total: 44.5; Opened: 45.5
    FPI favorite: Eagles by 1.7 with a 54.6% probability to win the game outright


    Cleveland Browns vs. Detroit Lions -8.5
    Sunday, 1 p.m., FOX


    Money Line: Browns (+360); Lions (-500)
    Total: 45.5; Opened: 45.5
    FPI favorite: Lions by 10.8 with a 75.73% probability to win the game outright


    Carolina Panthers vs. New England Patriots -5.5
    Sunday, 1 p.m., FOX


    Money Line: Panthers (+195); Patriots (-230)
    Total: 43.5; Opened: 44.5
    FPI favorite: Patriots by 2.4 with a 56.07% probability to win the game outright


    Tennessee Titans vs. Houston Texans -6.5
    Sunday, 1 p.m., CBS


    Money Line: Titans (+280); Texans (-360)
    Total: 39.5; Opened: 39.5
    FPI favorite: Texans by 7.9 with a 69.67% probability to win the game outright


    Jacksonville Jaguars vs. San Francisco 49ers -3.5
    Sunday, 4:05 p.m., FOX


    Money Line: Jaguars (+150); 49ers (-175)
    Total: 46.5; Opened: 45.5
    FPI favorite: 49ers by 0.3 with a 50.07% probability to win the game outright


    Indianapolis Colts vs. Los Angeles Rams -3.5
    Sunday, 4:05 p.m., FOX


    Money Line: Colts (+160); Rams (-190)
    Total: 48.5; Opened: 48.5
    FPI favorite: Rams by 2.6 with a 57.2% probability to win the game outright


    Chicago Bears vs. Las Vegas Raiders -1.5
    Sunday, 4:25 p.m., CBS


    Line movement: Opened Bears -1.5

    Money Line: Bears (-105); Raiders (-115)
    Total: 47.5; Opened: 47.5
    FPI favorite: Bears by 0.6 with a 51.6% probability to win the game outright


    Baltimore Ravens -2.5 vs. Kansas City Chiefs
    Sunday, 4:25 p.m., CBS


    Money Line: Ravens (-150); Chiefs (+130)
    Total: 48.5; Opened: 48.5
    FPI favorite: Ravens by 0.6 with a 50.98% probability to win the game outright


    Green Bay Packers -6.5 vs. Dallas Cowboys
    Sunday, 8:20 p.m., NBC


    Money Line: Packers (-275); Cowboys (+225)
    Total: 47.5; Opened: 48.5
    FPI favorite: Packers by 3.5 with a 58.8% probability to win the game outright


    New York Jets vs. Miami Dolphins -2.5
    Monday, 7:15 p.m., ESPN


    Money Line: Jets (+120); Dolphins (-140)
    Total: 45.5; Opened: 44.5
    FPI favorite: Dolphins by 2.3 with a 56.8% probability to win the game outright


    Cincinnati Bengals vs. Denver Broncos -7.5
    Monday, 8:15 p.m., ABC


    Money Line: Bengals (+290); Broncos (-380)
    Total: 44.5; Opened: 44.5
    FPI favorite: Broncos by 8.8 with a 72% probability to win the game outright

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